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In the small intestine, pancreatic proteases partially degrade the R proteins, releasing B12 to bind with another protein called intrinsic factor

These findings indicate that our AuNPs are taken up by cells and reside in the cytoplasm

After three to four freeze-thaw cycles, even a high-purity peptide will show aggregation upon reconstitution

We are pleased to have been involved in producing the new guideline, and we will be participating in producing a new Guideline on the Treatment of Cobalamin and Folate Disorders later this year.

Acknowledgements This work was supported by Science and Engineering Research Board (SERB) project no: SB/YS/LS-194/2013